A pharmacy at a Costco retailer in Teterboro, New Jersey, US, on Wednesday, Feb. 28, 2024.
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As extra People use GLP-1 weight-loss medicine to shrink their waistlines, retail giants are betting on a bottom-line bump tied to a shift in the way in which the medicine are priced and bought. Employers are dropping protection for GLP-1 medicine like Wegovy and Zepbound in better numbers, nudging extra sufferers to direct-to-consumer prescription applications, and offering Walmart, Costco, CVS and Amazon the chance to realize a better share of the market.
For the retail pharmacy chains, a GLP-1 prescription is evolving into greater than a easy sale — it is making a beachhead to growing buyer relationships that may run for years and pull customers towards all the things else on the shelf. If a buyer goes to get their GLP-1s from Walmart, they may as effectively get all their different prescriptions and cargo up on deodorant, paper towels, and condiments.
“Retailers are betting that if they will turn into the entrance door for weight problems care, they’re going to earn a relationship that extends far past a single GLP-1 prescription,” mentioned Eric Bormel, managing director specializing in digital healthcare at Solomon Companions’ healthcare group.
The DTC GLP-1 applications are buyer acquisition instruments, Bormel mentioned, and retailers are more and more valuing your entire ecosystem across the medicine greater than the medicine itself, which is experiencing downward value strain.
“Everybody acknowledges that weight problems remedy is changing into a longitudinal shopper relationship,” Bormel mentioned, noting that retailers aren’t merely combating over the identical clients, however bringing in new ones via the GLP-1 enterprise. It is one of many enterprise tailwinds that’s in stark distinction to preliminary considerations that GLP-1s have been a headwind for retailers as shoppers in the reduction of on impulse buys and total grocery spending.
New clothes wants is a method that retailers stand to profit from GLP-1 utilization. However the want for prescription refills matches into a good broader technique for giant retail pharmacy networks which were betting the weight-loss drug growth, even at low margins, will repay for his or her companies.
“In a retail trade that spends billions chasing foot site visitors, that’s the most dependable recurring buyer relationship in the marketplace,” mentioned Jackie Swanson, managing associate at Gartner Consulting.
The prescription refill is a retail one-of-a-kind
Walmart changing into the retail pickup level for LillyDirect issues as a result of the affected person who collects a prescription walks via the shop to achieve it. “Pharmacy lock-in is loyalty-program economics utilized to medication, and it really works as a result of the refill, in contrast to virtually all the things else in retail, is non-negotiable,” Swanson mentioned.
She notes LillyDirect’s money costs, which run $299 to $449 a month, with the higher pricing tied to refilling inside 45 days. “Which is a loyalty program dressed as a reduction schedule,” Swanson mentioned.
Novo Nordisk’s NovoCare has a $199 value for introductory months, which later steps as much as $349, a “traditional acquisition funnel,” Swanson mentioned.
In the meantime, Costco’s Sesame partnership costs Wegovy at round $349 and requires a membership. “So the prescription now helps promote the $65 card,” Swanson mentioned.

Swanson says that, for patrons, the low cost is actual, and for chains, what’s a deal for patrons is a deal for them, too: a minimal acquisition price for a long-term relationship.
“When a reduction is tied to a community, the affected person’s alternative of pharmacy occurs at sign-up, not on the counter, and that is a significant change for any pharmacy that has traditionally received enterprise via service and proximity. The economics of those applications favor scale,” Swanson mentioned. “The retailer that fills the prescription tends to promote the groceries too, and pharmacy is quietly changing into the membership battleground of American retail,” Swanson added.
Walmart, the nation’s fifth-largest prescription supplier with practically 4,600 pharmacies, has moved aggressively to seize this shift. In April, the retailer expanded its Higher Care Providers digital platform to bundle GLP-1 prescriptions with weight-management help like vitamin teaching, health apps, and AI-driven teaching instruments, whereas positioning itself as a one-stop vacation spot fairly than only a pickup counter. In keeping with the latest revealed knowledge from Drug Channels Institute, a pharmacy trade analysis agency, Walmart at present holds 4.8% of the pharmacy market, effectively behind CVS’s 14.7% and Walgreens’ 14.6%. The DTC GLP-1 provides Walmart a brand new instrument to attempt to catch up.
Amazon, which has spent years trying to extend its healthcare footprint, is focusing on the chance as effectively. In April, the corporate launched a GLP-1 administration program via Amazon One Medical, the first care enterprise it acquired in 2022, and Amazon Pharmacy, providing insured sufferers costs as little as $25 a month and offering same-day supply in practically 3,000 cities, increasing to 4,500 by 12 months’s finish.
Capital from retailers is flowing into weight-management platforms, digital weight problems care, vitamin teaching, metabolic well being options, and employer care administration applications.
Large retail has struggled to make healthcare worthwhile
The concentrate on GLP-1s from the most important retailers shouldn’t be new. Way back to 2023, then-Walmart CEO Doug McMillon mentioned the corporate anticipated weight reduction medicine to assist drive gross sales. However that did not essentially translate into profitability. “Gross sales {dollars} are rather a lot greater than the margin {dollars},” mentioned Kroger CEO Rodney McMullen at the moment. “The affect on profitability is fairly slim,” he mentioned.
The large retailers have additionally struggled up to now to seize a broader slice of the healthcare pie. Walmart shuttered its Walmart Well being clinics and digital care service fully in 2024, closing all 51 places throughout six states after concluding the primary-care enterprise wasn’t sustainable amid reimbursement pressures and rising prices — 5 years after it first opened the clinics.
Amazon’s historical past of healthcare efforts consists of shutting down its Amazon Care telehealth service on the finish of 2022, simply weeks after unveiling its $3.9 billion deal for One Medical. Years earlier, it walked away from Haven, its joint well being care enterprise with JPMorgan Chase and Berkshire Hathaway, which dissolved in 2021 with out producing the associated fee financial savings the three corporations had promised.
CVS has needed to shutter a lot of its instore Minute Clinics and the corporate has had its share of different struggles through the years with making an attempt to make healthcare as worthwhile as paper towels or back-to-school provides.
Swanson mentioned the timing of those DTC efforts dovetails with employers leaving the area. A survey by Mercer final month confirmed 6% of huge employers dropped GLP-1 protection this 12 months, with the medicine’ share of claims swelling to 11.4% from the 6.9% determine it was at in 2023. Extra employers have balked at paying for them as a result of so many individuals might be eligible for the remedies and plenty of sufferers cease them after reaching a weight-loss purpose. Medical health insurance firm Cigna mentioned earlier this month it could cease overlaying the medicines for its personal workers.
Extra employers are pointing staff to the direct-to-consumer platforms.
“Each affected person who loses protection is selecting a brand new entrance door for care this 12 months, and retailers are competing to be that door on the actual second of the choice. Actual affordability will get delivered; a buyer relationship will get acquired; each statements are true concurrently,” Swanson mentioned.
As employers balk at price, native pharmacies lose
Seth Friedman, pharmacy & well being plan providers follow chief at Gallagher, says on the opposite facet of the chance for the retail chains are the impartial pharmacies and non-chain gamers, who stand to be the massive losers on this shift. “Smaller pharmacies stand to lose quantity for positive,” Friedman mentioned.
Dared Value, who owns 9 pharmacies situated in small Kansas cities like Winfield, inhabitants 11,000, mentioned he’s already feeling the affect as clients race to the massive chains for his or her GLP-1s. “It’s irritating to me to not have the ability to present the identical entry to our sufferers that they do to CVS or Costco,” Value mentioned. “It places impartial pharmacies at an enormous drawback.”
Value mentioned the shift creates a doubtlessly harmful scenario for some sufferers. “If certainly one of my clients needs to do a DTC program and has to go to CVS or Costco, these pharmacies haven’t got entry to the remainder of their portfolio,” Value mentioned. Value, for his half, has no method of realizing whether or not a buyer is taking GLP-1 medicine if they’re getting them from large pharmacies. “My system will not flag any drug interactions with GLP medicine and there are drug interactions that may be harmful,” he mentioned, including it is a severe concern provided that there are recognized interactions with different medicine like insulin or oral contraceptives that might be problematic.
CVS, nonetheless, says its pharmacists are able to deal with the entire affected person. “Entry is barely a part of the equation with GLP-1 medicines. Sufferers additionally want help to remain on remedy and see outcomes,” mentioned Sid Tenneti, senior vp and interim president, pharmacy and shopper wellness, in a press release shared by a CVS spokesperson.
“Participation in NovoCare is a method we’re helping sufferers, however we’re additionally taking part in Medicare Bridge and settle for most third-party prescription low cost playing cards,” the CVS spokesperson added.
That program, a brand new Facilities for Medicare & Medicaid Providers initiative launched July 1, providing eligible Medicare sufferers GLP-1s for weight reduction at a flat $50 month-to-month copay, runs via a single central processor fairly than via a affected person’s common pharmacy of report, the sort of structural hole that worries some obesity-care specialists.

Some specialists worry the concentrate on the bottom potential value for GLPs obscures the bigger healthcare wants of sufferers even when pharmacies promise to observe the entire affected person.
“My view on that is that the medicine aren’t the answer by themselves; they’re a robust instrument. However the medicine alone does not work that effectively. Individuals do a lot better when cared for by knowledgeable clinicians,” mentioned Elina Onitskansky, founder & CEO of Ilant Well being, an obesity-care heart.
Onitskansky mentioned she understands why chains have an interest within the GLPs, however the race for the bottom value has created a “gold rush” mentality, and she or he worries that sufferers who take part within the DTC applications are leaving worthwhile details about their well being behind, leaving pharmacists at an obstacle. “I do not assume fragmentation helps,” she mentioned.
Value says the pharmaceutical giants wish to signal one contract and get 2,000 shops, however there are associations of smaller pharmacies with many members that might enter into comparable DTC applications, however to this point there’s been no motion. “There are not any good applications for independents. It’s a travesty that there [aren’t],” Value mentioned.
—CNBC’s Angelica Peebles contributed to this report.